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In summary, The classical view of the gene concept (Inistrumental gene) begins with the work of Mendel (1866), According Mendel, Gene is distinct, discrete entities (factor) that specify characteristics In 1900, three biologists working independently— Hugo de Vries, Carl Correns, and Erich von Tschermak—rediscovered Mendel’s principle and introduced the preformationist notion of organisms composed of ‘‘unit characters,’’ for each of which pangenes existed (the unit of inheritance as the ‘unit character). 1909, the term ``gene'' was coined by Johannsen. He wished this unit of heredity to be free of any hypotheses regarding its physical or chemical nature, that is, that the genes should be treated as calculating units. However, up to that era, genes were hypothetical material constituents of the cell whose physical transmission from parent to offspring causally explained the Mendelian pattern of inheritance. In his Nobel Prize acceptance speech Thomas Hunt Morgan, the father of classical genetics, noted, ‘‘There is not consensus of opinion amongst geneticists as to what genes are – whether they are real or purely fictitious – because at the level at which genetic experiments lie, it does not make the slightest difference whether the gene is a hypothetical unit, or whether the gene is a material particle’’.