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The goal of pharmacogenetics of antihypertensive drugs is to implement patient’s genetic data into predicting optimal dosage for a drug with a narrow therapeutic index, selecting the right drugs for a given patient, & reducing cost of treatments. As consequence, numerous studies reported significant associations of ACE (I/D), AGN (M235T), AT1 (A1166C), ADRB1 (Arg389Gly Ser49Gly) &ADD1 (Gly460Trp) with different antihypertensive drugs response; however, pharmacogenetics data emerging from these studies have been mostly inconsistent, and to date no the effects of single gene or combined effects of all presently known polymorphisms accounting for a significant proportion of variation in blood pressure response to a given drug has been identified. In a this reviews of pharmacogenetics of anti-hypertensive drugs response, the reviewers reported that these consistent findings are emerging from differences in study designs, variable methods for assessing pharmacologic exposures, heterogeneous phenotypes (that is, response variables and outcomes ranging from blood pressure to clinical outcomes), several gene-treatment combinations, and small sample sizes coupled with a short duration of follow-up in many studies account for a large portion of these inconsistencies. Furthermore, the reviewers reported that progress in the future will depend upon our ability to launch large studies using high-fidelity phenotyping with multiple drugs and multiple ethnic groups.